Kcne3tm1.1Tjj
Targeted Allele Detail
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Symbol: |
Kcne3tm1.1Tjj |
Name: |
potassium voltage-gated channel, Isk-related subfamily, gene 3; targeted mutation 1.1, Thomas J Jentsch |
MGI ID: |
MGI:4456241 |
Gene: |
Kcne3 Location: Chr7:99825714-99834076 bp, + strand Genetic Position: Chr7, 54.33 cM, cytoband F1
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Alliance: |
Kcne3tm1.1Tjj page
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Cre mediated recombination removed exon 4 and the neo cassette. The absence of protein expression was confirmed by western blot analysis on jejunum, ileum. colon, stomach, and trachea extracts.
(J:160721)
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Generation of the Kcne3tm1Tjj and Kcne3tm1.1Tjj alleles |
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Loading... | | | involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J | |
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Phenotypes: |
Affected Systems |
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digestive/alimentary system
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abnormal digestive system physiology
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abnormal intestine physiology
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homeostasis/metabolism
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abnormal physiological response to xenobiotic
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respiratory system
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abnormal respiratory system physiology
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Kcne3 Mutation: |
11 strains or lines available
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Original: |
J:160721 Preston P, et al., Disruption of the K+ channel beta-subunit KCNE3 reveals an important role in intestinal and tracheal Cl- transport. J Biol Chem. 2010 Mar 5;285(10):7165-75 |
All: |
3 reference(s) |
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