Kcne3^tm1.1Tjj
Targeted Allele Detail

Summary

• Symbol: Kcne3^tm1.1Tjj
• Name: potassium voltage-gated channel, Isk-related subfamily, gene 3; targeted mutation 1.1, Thomas J Jentsch
• MGI ID: MGI:4456241
• Gene: Kcne3 Location: Chr7:99825714-99834076 bp, + strand Genetic Position: Chr7, 54.33 cM, cytoband F1
• Alliance: Kcne3^tm1.1Tjj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160721
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Cre mediated recombination removed exon 4 and the neo cassette. The absence of protein expression was confirmed by western blot analysis on jejunum, ileum. colon, stomach, and trachea extracts. (J:160721)

Generation of the Kcne3^tm1Tjj and Kcne3^tm1.1Tjj alleles

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcne3 Mutation: 11 strains or lines available

References

• Original: J:160721 Preston P, et al., Disruption of the K+ channel beta-subunit KCNE3 reveals an important role in intestinal and tracheal Cl- transport. J Biol Chem. 2010 Mar 5;285(10):7165-75
• All: 3 reference(s)