Dusp4^tm1Jmol
Targeted Allele Detail

Summary

• Symbol: Dusp4^tm1Jmol
• Name: dual specificity phosphatase 4; targeted mutation 1, Jeffery D Molkentin
• MGI ID: MGI:4456264
• Synonyms: Mkp2^-
• Gene: Dusp4 Location: Chr8:35274451-35287048 bp, + strand Genetic Position: Chr8, 21.16 cM
• Alliance: Dusp4^tm1Jmol page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140567
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Not Specified
• Mutation details: Exons 2 and 3 were replaced with a neomycin cassette via homologous recombination. RT-PCR confirmed the absence of transcript expression in the heart. (J:140567, J:200367)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dusp4 Mutation: 22 strains or lines available

References

• Original: J:140567 Ramesh S, et al., TGFbeta-mediated BIM expression and apoptosis are regulated through SMAD3-dependent expression of the MAPK phosphatase MKP2. EMBO Rep. 2008 Oct;9(10):990-7
• All: 8 reference(s)