Tg(KRT5-IKBKB)2Armz
Transgene Detail

Summary

• Symbol: Tg(KRT5-IKBKB)2Armz
• Name: transgene insertion 2, Angel Ramirez
• MGI ID: MGI:4456368
• Transgene: Tg(KRT5-IKBKB)2Armz Location: unknown Genetic Position: ChrX, Syntenic
• Alliance: Tg(KRT5-IKBKB)2Armz page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT5-IKBKB)2Armz expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IKBKB (3551)

  Ikbkb

  (MGI:1338071)

• Tg(KRT5-IKBKB)2Armz expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  cattle	KRT5 (281268)

• Mutation details: This transgene expresses N-terminal vesicular stomatitis virus (VSV) epitope-tagged human inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (IKBKB) under control of the 5.2 kb 5' upstream fragment of the bovine keratin 5 (KRT5) gene and a rabbit b-globin intron. Line 2 incorporated the transgene into the X Chromosome. Immunohistochemical analysis using antibodies against IKBKB or the VSV epitope revealed expression of the protein in basal cells of the skin and of other stratified epithelia (e.g., palate and forestomach) and in hair follicles. (J:160072)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:160072 Page A, et al., IKKbeta leads to an inflammatory skin disease resembling interface dermatitis. J Invest Dermatol. 2010 Jun;130(6):1598-610
• All: 2 reference(s)