Sox10^{tm6(Sox100B)Weg}
Targeted Allele Detail

Summary

• Symbol: Sox10^{tm6(Sox100B)Weg}
• Name: SRY (sex determining region Y)-box 10; targeted mutation 6, Michael Wegner
• MGI ID: MGI:4456384
• Synonyms: Sox10^Sox100B
• Gene: Sox10 Location: Chr15:79039113-79048690 bp, - strand Genetic Position: Chr15, 37.7 cM
• Alliance: Sox10^{tm6(Sox100B)Weg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160023
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding exons were replaced with the open reading frame of Drosophila Sox100B, an IRES-EGFP, and a floxed neo cassette. (J:160023)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox10 Mutation: 33 strains or lines available

References

• Original: J:160023 Cossais F, et al., Replacement of mouse Sox10 by the Drosophila ortholog Sox100B provides evidence for co-option of SoxE proteins into vertebrate-specific gene-regulatory networks through altered expression. Dev Biol. 2010 May 1;341(1):267-81
• All: 1 reference(s)