Rr155^tm1.1Erpi
Targeted Allele Detail

Summary

• Symbol: Rr155^tm1.1Erpi
• Name: regulatory region 155; targeted mutation 1.1, Eric Pinaud
• MGI ID: MGI:4456430
• Synonyms: HS3bdelta, Igh^tm1.1Erpi
• Gene: Rr155 Location: Chr12:113195964-113196046 bp Genetic Position: Chr12, Syntenic
• Alliance: Rr155^tm1.1Erpi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160101
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The HS3b transcriptional enhancer, in the 3'RR (Rr152) downstream of the Ighc gene segments, was replaced with a loxP site flanked neomycin resistance gene cassette. Cre-mediated recombination removed the neo cassette. (J:160101)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr155 Mutation: 0 strains or lines available

References

• Original: J:160101 Bebin AG, et al., In vivo redundant function of the 3' IgH regulatory element HS3b in the mouse. J Immunol. 2010 Apr 1;184(7):3710-7
• All: 1 reference(s)