Tmed2^99J
Chemically induced Allele Detail

Summary

• Symbol: Tmed2^99J
• Name: transmembrane p24 trafficking protein 2; line 99J
• MGI ID: MGI:4456438
• Gene: Tmed2 Location: Chr5:124678835-124688566 bp, + strand Genetic Position: Chr5, 63.65 cM
• Alliance: Tmed2^99J page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Nucleotide substitutions
• Mutation details: ENU mutagenesis induced a C to A transversion in exon 1 that results in the amino acid substitution of glutamic acid for alanine at position 12 (A13E). The absence of protein expression was confirmed by western blot analysis on E9.5 extracts. (J:160012)

Expression

In Mice Carrying this Mutation:	62 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmed2 Mutation: 8 strains or lines available

References

• Original: J:160012 Jerome-Majewska LA, et al., The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta. Dev Biol. 2010 May 1;341(1):154-66
• All: 5 reference(s)