Il6ra^tm1.1Drew
Targeted Allele Detail

Summary

• Symbol: Il6ra^tm1.1Drew
• Name: interleukin 6 receptor, alpha; targeted mutation 1.1, Angela Drew
• MGI ID: MGI:4456449
• Synonyms: Il6r^lox
• Gene: Il6ra Location: Chr3:89776631-89820503 bp, - strand Genetic Position: Chr3, 39.19 cM
• Alliance: Il6ra^tm1.1Drew page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160966
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 4, and a frt-flanked neomycin resistance (neo) cassette followed by a second loxP site downstream of exon 6 of the interleukin 6 receptor alpha chain (Il6ra) gene. Flp mediated recombination removed the neo cassette leaving exons 4 through 6 floxed. (J:160966)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il6ra Mutation: 35 strains or lines available

References

• Original: J:160966 McFarland-Mancini MM, et al., Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor. J Immunol. 2010 Jun 15;184(12):7219-28
• All: 47 reference(s)