Il6ra^tm1.2Drew
Targeted Allele Detail

Summary

• Symbol: Il6ra^tm1.2Drew
• Name: interleukin 6 receptor, alpha; targeted mutation 1.2, Angela Drew
• MGI ID: MGI:4456450
• Gene: Il6ra Location: Chr3:89776631-89820503 bp, - strand Genetic Position: Chr3, 39.19 cM
• Alliance: Il6ra^tm1.2Drew page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160966
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 through 6 were removed by cre mediated recombination. The absence of protein expression was confirmed by western blot analysis on liver and spleen extracts. (J:160966)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il6ra Mutation: 35 strains or lines available

References

• Original: J:160966 McFarland-Mancini MM, et al., Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor. J Immunol. 2010 Jun 15;184(12):7219-28
• All: 5 reference(s)