Ikzf2^tm1.1Etms
Targeted Allele Detail

Summary

• Symbol: Ikzf2^tm1.1Etms
• Name: IKAROS family zinc finger 2; targeted mutation 1.1, Ethan M Shevach
• MGI ID: MGI:4456473
• Synonyms: Ikzf2^fl
• Gene: Ikzf2 Location: Chr1:69570373-69726404 bp, - strand Genetic Position: Chr1, 34.9 cM
• Alliance: Ikzf2^tm1.1Etms page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160098
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 8 and an frt flanked neo cassette with a 3' loxP site was inserted downstream of exon 8. Flp mediated recombination removed the neo cassette leaving exon 8 floxed. (J:160098)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ikzf2 Mutation: 41 strains or lines available

References

• Original: J:160098 Thornton AM, et al., Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J Immunol. 2010 Apr 1;184(7):3433-41
• All: 10 reference(s)