Faap20^tm1(KOMP)Mbp
Targeted Allele Detail

Summary

• Symbol: Faap20^tm1(KOMP)Mbp
• Name: Fanconi anemia core complex associated protein 20; targeted mutation 1, Mouse Biology Program, UC Davis
• MGI ID: MGI:4456552
• Gene: Faap20 Location: Chr4:155334259-155341144 bp, + strand Genetic Position: Chr4, 86.17 cM
• Alliance: Faap20^tm1(KOMP)Mbp page
• IMPC: Faap20 gene page

Mutation origin

• Mutant Cell Lines: DEPD00507_1_A09, DEPD00507_1_A10, DEPD00507_1_A11, DEPD00507_1_A12, DEPD00507_1_B09, DEPD00507_1_B11, DEPD00507_1_B12, DEPD00507_1_C09, DEPD00507_1_C10, DEPD00507_1_C11, DEPD00507_1_D09, DEPD00507_1_D11, DEPD00507_1_D12, DEPD00507_1_E11, DEPD00507_1_E12, DEPD00507_1_F09, DEPD00507_1_F10, DEPD00507_1_F11, DEPD00507_1_F12, DEPD00507_1_G09, DEPD00507_1_G10, DEPD00507_1_G12, DEPD00507_1_H09
• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: JM8A3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 740 starting at position 155334923 and ending at position 155335663 of Chromosome 4 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157064, J:224688)

Expression

In Mice Carrying this Mutation:	27 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 1 line available
• Carrying any Faap20 Mutation: 18 strains or lines available

References

• Original: J:157064 University of California, Davis, Alleles produced for the KOMP project by the University of California, Davis. MGI Direct Data Submission. 2010
• All: 3 reference(s)