Hsd17b7^tm1Mpo
Targeted Allele Detail

Summary

• Symbol: Hsd17b7^tm1Mpo
• Name: hydroxysteroid (17-beta) dehydrogenase 7; targeted mutation 1, Matti Poutanen
• MGI ID: MGI:4456868
• Gene: Hsd17b7 Location: Chr1:169777109-169796757 bp, - strand Genetic Position: Chr1, 76.84 cM
• Alliance: Hsd17b7^tm1Mpo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160004
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neo cassette was inserted into exon 2. (J:160004)

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hsd17b7 Mutation: 18 strains or lines available

References

• Original: J:160004 Jokela H, et al., Hydroxysteroid (17beta) dehydrogenase 7 activity is essential for fetal de novo cholesterol synthesis and for neuroectodermal survival and cardiovascular differentiation in early mouse embryos. Endocrinology. 2010 Apr;151(4):1884-92
• All: 1 reference(s)