Pdcd1lg2^tm4Shr
Targeted Allele Detail

Summary

• Symbol: Pdcd1lg2^tm4Shr
• Name: programmed cell death 1 ligand 2; targeted mutation 4, Arlene H Sharpe
• MGI ID: MGI:4456974
• Synonyms: PDL1/L2
• Gene: Pdcd1lg2 Location: Chr19:29388319-29448561 bp, + strand Genetic Position: Chr19, 23.93 cM, cytoband C2-C3
• Alliance: Pdcd1lg2^tm4Shr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160970
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A targeting vector was designed to replace the the IgV exon with a hygromycin resistance gene in ES cells containing the Cd274^tm2Shr allele in which the CD274 antigen signal and two-thirds of the IgV exon were replaced with a neomycin cassette. (J:160970)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pdcd1lg2 Mutation: 25 strains or lines available

References

• Original: J:160970 Sharpe A, Generation of PD-L1/PD-L2 mutant. MGI Direct Data Submission. 2010
• All: 3 reference(s)