Irf6^clft1
Chemically induced Allele Detail

Summary

• Symbol: Irf6^clft1
• Name: interferon regulatory factor 6; cleft palate 1
• MGI ID: MGI:4457055
• Gene: Irf6 Location: Chr1:192835419-192854331 bp, + strand Genetic Position: Chr1, 97.6 cM
• Alliance: Irf6^clft1 page

Palatal defects in Irf6^clft1/Irf6^clft1 mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: A/J

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a C to T transition that results in the amino acid substitution of proline with leucine at position 39 (P39L). This allele is hypomorphic. (J:160190)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Irf6 Mutation: 26 strains or lines available

References

• Original: J:160190 Stottmann RW, et al., Identification of a Van der Woude syndrome mutation in the cleft palate 1 mutant mouse. Genesis. 2010 May;48(5):303-8
• All: 2 reference(s)