Slc6a4^{tm1(SLC6A4)Kres}
Targeted Allele Detail

Summary

• Symbol: Slc6a4^{tm1(SLC6A4)Kres}
• Name: solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; targeted mutation 1, Kerry Ressler
• MGI ID: MGI:4457111
• Synonyms: hSERT wt knockin
• Gene: Slc6a4 Location: Chr11:76889429-76923166 bp, + strand Genetic Position: Chr11, 46.18 cM
• Alliance: Slc6a4^{tm1(SLC6A4)Kres} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:331750
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Full-length wild-type human SLC6A4 cDNA replaces exons 2-6 of the targeted mouse gene. (J:331750)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc6a4 Mutation: 53 strains or lines available

References

• Original: J:331750 Murray KE, et al., In vivo investigation of escitalopram's allosteric site on the serotonin transporter. Pharmacol Biochem Behav. 2016 Feb;141:50-7
• All: 2 reference(s)