Tmprss6^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Tmprss6^tm1Dgen
• Name: transmembrane serine protease 6; targeted mutation 1, Deltagene
• MGI ID: MGI:4457116
• Synonyms: Tmprss6^-
• Gene: Tmprss6 Location: Chr15:78323867-78352834 bp, - strand Genetic Position: Chr15, 37.49 cM, cytoband E2
• Alliance: Tmprss6^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160248
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The genomic sequence spanning the 3' portion of exon 16 to the 5' portion of exon 17 was replaced. This deletion removed 74 amino acids of the protease domain. This allele is expected to produce a protein lacking protease activity. Reduced expression of a transcript lacking the targeted region was confirmed by QRT-PCR. (J:160248)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmprss6 Mutation: 46 strains or lines available

References

• Original: J:160248 Finberg KE, et al., Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis. Blood. 2010 May 6;115(18):3817-26
• All: 6 reference(s)