Tg(Alb1-Ren)3Unc
Transgene Detail

Summary

• Symbol: Tg(Alb1-Ren)3Unc
• Name: transgene insertion 3, University of North Carolina
• MGI ID: MGI:4457120
• Synonyms: RenTgARE
• Transgene: Tg(Alb1-Ren)3Unc Location: unknown
• Alliance: Tg(Alb1-Ren)3Unc page

Transgene origin

• Germline Transmission: Earliest citation of germline transmission: J:95789
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Transgene description

• Transgene Type: Transgenic
• Mutation: Insertion
• Mutation details: The transgene, inserted into the apolipoprotein locus between the Apoa1 and Apoc3 genes, comprises a single copy of a construct consisting of the liver specific albumin promoter/enhancer, a synthetic cDNA encoding a secreted, hybrid renin protein with a C-terminal Myc epitope tag, and, immediately downstream of the translation termination codon, a 75 bp synthetic AU rich element (ARE) including the domain I sequence of the RNA destabilizing element of the Fos gene, which reduces the half-life of the mRNA. (J:95789)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:95789 Caron KM, et al., Lifelong genetic minipumps. Physiol Genomics. 2005 Jan 20;20(2):203-9
• All: 1 reference(s)