Noxa1^tm1.2Brg
Targeted Allele Detail

Summary

• Symbol: Noxa1^tm1.2Brg
• Name: NADPH oxidase activator 1; targeted mutation 1.2, David E Bergstrom
• MGI ID: MGI:4457198
• Synonyms: Noxa1^del1
• Gene: Noxa1 Location: Chr2:24975679-24985161 bp, - strand Genetic Position: Chr2, 16.97 cM
• Alliance: Noxa1^tm1.2Brg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164059
• Parent Cell Line: PRX-B6-albino #1 (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J/J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A single loxP site was inserted into intron 2 and an FRT-flanked neomycin/kanamycin selection cassette with a second loxP site was inserted into intron 6. Exons 3 through 6, encoding amino acids 88-220, were excised by cre recombinase mediated excision. This is predicted to result in the incorporation of 19 novel amino acids followed by a premature stop codon. (J:164059)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Noxa1 Mutation: 20 strains or lines available

References

• Original: J:164059 Flaherty JP, et al., Generation of a conditional null allele of NADPH oxidase activator 1 (NOXA1). Genesis. 2010 Jul 19;:1-8
• All: 1 reference(s)