Mov10l1^tm1.2Jw
Targeted Allele Detail

Summary

• Symbol: Mov10l1^tm1.2Jw
• Name: Mov10 like RISC complex RNA helicase 1; targeted mutation 1.2, Jeremy Wang
• MGI ID: MGI:4457276
• Gene: Mov10l1 Location: Chr15:88867112-88939355 bp, + strand Genetic Position: Chr15, 44.49 cM
• Alliance: Mov10l1^tm1.2Jw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161125
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre mediated recombination removed exons 18 through 21. This allele is predicted to generate a protein lacking most of the ATPase and all of the unwindase domains. The absence of protein expression was confirmed by immunohistochemistry on adult testes. (J:161125)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mov10l1 Mutation: 46 strains or lines available

References

• Original: J:161125 Zheng K, et al., Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway. Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11841-6
• All: 5 reference(s)