Dnm1^tm2.1Pdc
Targeted Allele Detail

Summary

• Symbol: Dnm1^tm2.1Pdc
• Name: dynamin 1; targeted mutation 2.1, Pietro De Camilli
• MGI ID: MGI:4457321
• Synonyms: Dnm1^LoxP
• Gene: Dnm1 Location: Chr2:32198483-32243350 bp, - strand Genetic Position: Chr2, 22.09 cM
• Alliance: Dnm1^tm2.1Pdc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161127
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (C57BL/6 x 129S1/SvImJ)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 2-4 were flanked by loxP sites and an FRT-flanked neomycin resistance cassette was placed in intron 1. Flp mediated recombination removed the neo cassette leaving exons 2 through 4 floxed. (J:161127)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dnm1 Mutation: 40 strains or lines available

References

• Original: J:161127 Ferguson SM, et al., Coordinated actions of actin and BAR proteins upstream of dynamin at endocytic clathrin-coated pits. Dev Cell. 2009 Dec;17(6):811-22
• All: 14 reference(s)