Tcap^tm1Mkc
Targeted Allele Detail

Summary

• Symbol: Tcap^tm1Mkc
• Name: titin-cap; targeted mutation 1, Martin K Childers
• MGI ID: MGI:4457372
• Gene: Tcap Location: Chr11:98274637-98275779 bp, + strand Genetic Position: Chr11, 61.75 cM
• Alliance: Tcap^tm1Mkc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159687
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a lacZ-neo cassette. The absence of protein expression was confirmed by western blot analysis on muscle extracts. Immunohistochemistry confirmed the absence of protein expression in the liver, brain, and kidney. (J:159687)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcap Mutation: 9 strains or lines available

References

• Original: J:159687 Markert CD, et al., Functional muscle analysis of the Tcap knockout mouse. Hum Mol Genet. 2010 Jun 1;19(11):2268-83
• All: 1 reference(s)