Slc23a1^tm1Mlev
Targeted Allele Detail

Summary

• Symbol: Slc23a1^tm1Mlev
• Name: solute carrier family 23 (nucleobase transporters), member 1; targeted mutation 1, Mark Levine
• MGI ID: MGI:4457389
• Gene: Slc23a1 Location: Chr18:35747657-35760297 bp, - strand Genetic Position: Chr18, 19.17 cM
• Alliance: Slc23a1^tm1Mlev page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159697
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 through 12 were replaced with a neo cassette. The absence of transcript expression was confirmed by RT-PCR on liver, kidney, and small intestine extracts. (J:159697)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc23a1 Mutation: 27 strains or lines available

Notes

ES cell line = HGTC-8 (C57BL/6J)

References

• Original: J:159697 Corpe CP, et al., Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice. J Clin Invest. 2010 Apr;120(4):1069-83
• All: 1 reference(s)