Por^tm3Ding
Targeted Allele Detail

Summary

• Symbol: Por^tm3Ding
• Name: cytochrome p450 oxidoreductase; targeted mutation 3, Xinxin Ding
• MGI ID: MGI:4457492
• Synonyms: Cpr^r-CL
• Gene: Por Location: Chr5:135698894-135764180 bp, + strand Genetic Position: Chr5, 75.34 cM, cytoband G1
• Alliance: Por^tm3Ding page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159168
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted into intron 15. The reduction in protein expression was confirmed by western blot analysis on liver, kidney, brain, lung, and olfactory mucosa extracts. (J:159168)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Por Mutation: 80 strains or lines available

References

• Original: J:159168 Wei Y, et al., Generation of a mouse model with a reversible hypomorphic cytochrome P450 reductase gene: utility for tissue-specific rescue of the reductase expression, and insights from a resultant mouse model with global suppression of P450 reductase expression in extrahepatic tissues. J Pharmacol Exp Ther. 2010 Jul;334(1):69-77
• All: 2 reference(s)