Sav1^tm2.1Dlim
Targeted Allele Detail

Summary

• Symbol: Sav1^tm2.1Dlim
• Name: salvador family WW domain containing 1; targeted mutation 2.1, Dae-Sik Lim
• MGI ID: MGI:4457496
• Synonyms: WW45^flox
• Gene: Sav1 Location: Chr12:70011786-70033776 bp, - strand Genetic Position: Chr12, 28.94 cM, cytoband C3
• Alliance: Sav1^tm2.1Dlim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160325
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an frt flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. Flp mediated recombination removed the neo cassette leaving exon 2 floxed. (J:160325)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sav1 Mutation: 20 strains or lines available

References

• Original: J:160325 Lee KP, et al., The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis. Proc Natl Acad Sci U S A. 2010 May 4;107(18):8248-53
• All: 6 reference(s)