Clcn5^tm3.1Tjj
Targeted Allele Detail

Summary

• Symbol: Clcn5^tm3.1Tjj
• Name: chloride channel, voltage-sensitive 5; targeted mutation 3.1, Thomas J Jentsch
• MGI ID: MGI:4457505
• Synonyms: Clcn5^*
• Gene: Clcn5 Location: ChrX:7020049-7185597 bp, - strand Genetic Position: ChrX, 3.21 cM, cytoband F3-F4
• Alliance: Clcn5^tm3.1Tjj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160701
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 12 was replaced with one containing nucleotide substitutions that result in the amino acid substitutions of alanine for aspartic acid and methionine for lysine. An frt flanked neo cassette inserted upstream of exon 12 was removed by flp mediated recombination. These substitutions convert the C-terminus to that of Clcn3. (J:160701)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clcn5 Mutation: 17 strains or lines available

References

• Original: J:160701 Novarino G, et al., Endosomal chloride-proton exchange rather than chloride conductance is crucial for renal endocytosis. Science. 2010 Jun 11;328(5984):1398-401
• All: 1 reference(s)