Adamts12^tm1Agno
Targeted Allele Detail

Summary

• Symbol: Adamts12^tm1Agno
• Name: ADAM metallopeptidase with thrombospondin type 1 motif 12; targeted mutation 1, Agnes Noel
• MGI ID: MGI:4457760
• Gene: Adamts12 Location: Chr15:11064876-11349317 bp, + strand Genetic Position: Chr15, 5.43 cM
• Alliance: Adamts12^tm1Agno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160778
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 6 and 7 were replaced with a neo cassette. The absence of transcript expression was confirmed by RT-PCR on ovary, mammary gland, uterus, lung, ear, and lymph node extracts. (J:160778)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adamts12 Mutation: 88 strains or lines available

References

• Original: J:160778 El Hour M, et al., Higher sensitivity of Adamts12-deficient mice to tumor growth and angiogenesis. Oncogene. 2010 May 20;29(20):3025-32
• All: 6 reference(s)