Rpgr^tm1Wbrg
Targeted Allele Detail

Summary

• Symbol: Rpgr^tm1Wbrg
• Name: retinitis pigmentosa GTPase regulator; targeted mutation 1, Wolfgang Berger
• MGI ID: MGI:4458091
• Synonyms: Rpgr^deltaexon4
• Gene: Rpgr Location: ChrX:10024455-10083034 bp, - strand Genetic Position: ChrX, 4.62 cM
• Alliance: Rpgr^tm1Wbrg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160802
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 was replaced with a neo cassette. The absence of RNA transcripts containing exon 4 was confirmed by RT-PCR on retinal extracts. (J:160802)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rpgr Mutation: 10 strains or lines available

References

• Original: J:160802 Brunner S, et al., Cone versus rod disease in a mutant Rpgr mouse caused by different genetic backgrounds. Invest Ophthalmol Vis Sci. 2010 Feb;51(2):1106-15
• All: 1 reference(s)