Dact1^tm1Yegc
Targeted Allele Detail

Summary

• Symbol: Dact1^tm1Yegc
• Name: dishevelled-binding antagonist of beta-catenin 1; targeted mutation 1, Ye-Guang Chen
• MGI ID: MGI:4458394
• Gene: Dact1 Location: Chr12:71356658-71366881 bp, + strand Genetic Position: Chr12, 29.39 cM
• Alliance: Dact1^tm1Yegc page

Urogenital defects and posterior malformation with a shorter notochord and vertebrae defects in Dact1^tm1Yegc/Dact1^tm1Yegc mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161177
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette replaces exon 1 and some flanking sequence. The absence of transcript expression was confirmed by whole mount in situ hybridization on embryos. (J:161177)

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	22 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dact1 Mutation: 21 strains or lines available

References

• Original: J:161177 Wen J, et al., Loss of Dact1 disrupts planar cell polarity signaling by altering dishevelled activity and leads to posterior malformation in mice. J Biol Chem. 2010 Apr 2;285(14):11023-30
• All: 2 reference(s)