Ret^{tm3.1(Bcl2l1)Heno}
Targeted Allele Detail

Summary

• Symbol: Ret^{tm3.1(Bcl2l1)Heno}
• Name: ret proto-oncogene; targeted mutation 3.1, Hideki Enomoto
• MGI ID: MGI:4459031
• Synonyms: Ret^Bcl-xL
• Gene: Ret Location: Chr6:118128706-118174679 bp, - strand Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
• Alliance: Ret^{tm3.1(Bcl2l1)Heno} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159854
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The cDNA and a floxed neo cassette was inserted into the first coding exon. Cre mediated recombination removed the neo cassette. Immunohistochemistry confirmed increased Bcl2l1 protein expression in enteric ganglia of heterozygous mice. (J:159854)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ret Mutation: 54 strains or lines available

References

• Original: J:159854 Uesaka T, et al., Neural precursor death is central to the pathogenesis of intestinal aganglionosis in Ret hypomorphic mice. J Neurosci. 2010 Apr 14;30(15):5211-8
• All: 3 reference(s)