Esr1^tm1Sakh
Targeted Allele Detail

Summary

• Symbol: Esr1^tm1Sakh
• Name: estrogen receptor 1 (alpha); targeted mutation 1, Sohaib A Khan
• MGI ID: MGI:4459300
• Synonyms: ERalpha^fl
• Gene: Esr1 Location: Chr10:4561989-4955633 bp, + strand Genetic Position: Chr10, 2.03 cM
• Alliance: Esr1^tm1Sakh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124962
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and a floxed PGK-neomycin selection cassette was inserted downstream of the same exon. The PGK-neo cassette was then exised from propeerly targeted ES cells leaving exon 3 floxed. (J:124962)

Expression

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Esr1 Mutation: 68 strains or lines available

References

• Original: J:124962 Feng Y, et al., Estrogen receptor-{alpha} expression in the mammary epithelium is required for ductal and alveolar morphogenesis in mice. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14718-23
• All: 29 reference(s)