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Il13tm1(YFP/cre)Lky
Targeted Allele Detail
Summary
Symbol: Il13tm1(YFP/cre)Lky
Name: interleukin 13; targeted mutation 1, Richard M Locksley
MGI ID: MGI:4459318
Synonyms: YetCre-13
Gene: Il13  Location: Chr11:53522151-53525529 bp, - strand  Genetic Position: Chr11, 31.98 cM
Alliance: Il13tm1(YFP/cre)Lky page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:161387
Parent Cell Line:  PC3 (ES Cell)
Strain of Origin:  129S4/SvJae-Tg(Prm-cre)70Og
Mutation
description
Allele Type:    Targeted (No functional change, Recombinase, Reporter)
Mutation:    Insertion
 
Il13tm1(YFP/cre)Lky expression driven by 1 gene
 
Mutation detailsA targeting construct containing a bicistronic reporter/recombinase cassette (loxP-Neo-loxP IRES-YFP-cre cassette and DTA negative-selection cassette with appropriate homology arms) was electroporated into ES cells containing a Prm-cre transgene. Homologous recombination resulted in insertion of the IRES-YFP-cre sequence between the translational stop codon and the 3'UTR of the Il13 gene, preserving the normal function of the gene yet allowing expression of the YFP/cre fusion protein. The floxed Neo cassette was deleted in the male germline (by Prm-cre) when chimeras were bred to wild-type females. (J:161387)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Il13 (mouse)
Summary of all recombinase alleles driven by Il13.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il13 Mutation:  30 strains or lines available
References
Original:  J:161387 Price AE, et al., Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11489-94
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory