Shoc2^tm1.1Mhan
Targeted Allele Detail

Summary

• Symbol: Shoc2^tm1.1Mhan
• Name: Shoc2, leucine rich repeat scaffold protein; targeted mutation 1.1, Min Han
• MGI ID: MGI:4459449
• Synonyms: Sur-8^flox
• Gene: Shoc2 Location: Chr19:53932737-54021564 bp, + strand Genetic Position: Chr19, 48.83 cM
• Alliance: Shoc2^tm1.1Mhan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161211
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exon 3 of the Shoc2 (Sur-8) gene. The targeting vector also contained an frt-flanked neomycin resistance cassette. The vector was electroporated into W4 ES cells. Mutant mice were crossed to Actin-FLPe transgenic mice to remove the neo cassette, leaving the floxed allele. (J:161211)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Shoc2^tm1.1Mhan

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Shoc2 Mutation: 43 strains or lines available

References

• Original: J:161211 Yi J, et al., Endothelial SUR-8 acts in an ERK-independent pathway during atrioventricular cushion development. Dev Dyn. 2010 Jul;239(7):2005-13
• All: 2 reference(s)