Dot1l^tm1.1Tche
Targeted Allele Detail

Summary

• Symbol: Dot1l^tm1.1Tche
• Name: DOT1 like histone lysine methyltransferase; targeted mutation 1.1, Taiping Chen
• MGI ID: MGI:4459468
• Synonyms: Dot1L^1lox
• Gene: Dot1l Location: Chr10:80591040-80631295 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Dot1l^tm1.1Tche page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161427
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre mediated recombination removed exon 5, exon 6, and the beta-geo cassette. The predicted protein product is expected to lack several conserved motifs in the Dot1L catalytic domain, including the SAM-binding motif and motifs X, I, and II. (J:161427)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dot1l Mutation: 72 strains or lines available

References

• Original: J:161427 Jones B, et al., The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure. PLoS Genet. 2008;4(9):e1000190
• All: 5 reference(s)