Igf1^tm1.1Nros
Targeted Allele Detail

Summary

• Symbol: Igf1^tm1.1Nros
• Name: insulin-like growth factor 1; targeted mutation 1.1, Nadia Rosenthal
• MGI ID: MGI:4459503
• Gene: Igf1 Location: Chr10:87694127-87772904 bp, + strand Genetic Position: Chr10, 43.7 cM
• Alliance: Igf1^tm1.1Nros page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159167
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was floxed and a FRT-flanked PGK-neomycin-resistance cassette was inserted within intron 2 before the 3' loxP site. The floxed exon and neomycin selection cassette were removed by cre-mediated recombination. No Class 2 IGF-1 was detected by RT-PCR of liver tissue. (J:159167)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igf1 Mutation: 29 strains or lines available

References

• Original: J:159167 Temmerman L, et al., Class 2 IGF-1 isoforms are dispensable for viability, growth and maintenance of IGF-1 serum levels. Growth Horm IGF Res. 2010 Jun;20(3):255-63
• All: 1 reference(s)