Rnf128^tm1Cdon
Targeted Allele Detail

Summary

• Symbol: Rnf128^tm1Cdon
• Name: ring finger protein 128; targeted mutation 1, Chen Dong
• MGI ID: MGI:4459531
• Gene: Rnf128 Location: ChrX:138464089-138573894 bp, + strand Genetic Position: ChrX, 61.35 cM
• Alliance: Rnf128^tm1Cdon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160681
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 4 and all of exons 5 and 6 were replaced with the neomycin resistance gene by homologous recombination. This removed amino acids 283-385, which contains much of the RING domain from the protein product. RT-PCR analysis of various tissues confirmed the region was removed. (J:160681)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnf128 Mutation: 10 strains or lines available

References

• Original: J:160681 Nurieva RI, et al., The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation. Immunity. 2010 May 28;32(5):670-80
• All: 3 reference(s)