Batf^tm1.1Ejt
Targeted Allele Detail

Summary

• Symbol: Batf^tm1.1Ejt
• Name: basic leucine zipper transcription factor, ATF-like; targeted mutation 1.1, Elizabeth J Taparowsky
• MGI ID: MGI:4459733
• Synonyms: Batf^{delta Z}
• Gene: Batf Location: Chr12:85733494-85755861 bp, + strand Genetic Position: Chr12, 39.78 cM
• Alliance: Batf^tm1.1Ejt page

Low IgG1 and IgG2c levels in spleen and absence of germinal centers in sRBC-immunized Batf^tm1.1Ejt/Batf^tm1.1Ejt mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160935
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/Sv

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted into intron 2 and a loxP site flanked neomycin resistance gene cassette into intron 3. HA epitope sequence was added to the the 3' end of the coding region in exon 3. Exon 3 and the neo cassette were removed by cre-mediated recombination. Immunoblots of splenocytes failed to detect any protein. (J:160935)

Generation of the Batf^tm1.1Ejt allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Batf Mutation: 14 strains or lines available

References

• Original: J:160935 Betz BC, et al., Batf coordinates multiple aspects of B and T cell function required for normal antibody responses. J Exp Med. 2010 May 10;207(5):933-42
• All: 7 reference(s)