Lrp1b^tm1Wtsi
Targeted Allele Detail

Summary

• Symbol: Lrp1b^tm1Wtsi
• Name: low density lipoprotein-related protein 1B; targeted mutation 1, Wellcome Trust Sanger Institute
• MGI ID: MGI:4459742
• Gene: Lrp1b Location: Chr2:40485258-42543636 bp, - strand Genetic Position: Chr2, 24.51 cM, cytoband B
• Alliance: Lrp1b^tm1Wtsi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160170
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

Allele Type: Targeted (Null/knockout) Mutation: Insertion Mice carry an internal duplication of exons 6-8 of Lrp1b predicted to cause frameshift mutations (J:91707, J:160170)

Generation of the Lrp1b^tm1Wtsi allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrp1b Mutation: 304 strains or lines available

References

• Original: J:160170 Dietrich MF, et al., Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo. PLoS One. 2010;5(4):e9960
• All: 2 reference(s)