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Lrp1btm2Wtsi
Targeted Allele Detail
Summary
Symbol: Lrp1btm2Wtsi
Name: low density lipoprotein-related protein 1B; targeted mutation 2, Wellcome Trust Sanger Institute
MGI ID: MGI:4459800
Gene: Lrp1b  Location: Chr2:40485258-42543636 bp, - strand  Genetic Position: Chr2, 24.51 cM, cytoband B
Alliance: Lrp1btm2Wtsi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:160170
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsMice carry an internal duplication of exon 69 of Lrp1b, based on the Ensembl predicted gene structure predicted to cause frameshift mutations. (J:91707, J:160170)
Generation of the Lrp1btm2Wtsi allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrp1b Mutation:  302 strains or lines available
References
Original:  J:160170 Dietrich MF, et al., Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo. PLoS One. 2010;5(4):e9960
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory