Timd4^tm1Kuch
Targeted Allele Detail

Summary

• Symbol: Timd4^tm1Kuch
• Name: T cell immunoglobulin and mucin domain containing 4; targeted mutation 1, Vijay Kuchroo
• MGI ID: MGI:4459812
• Synonyms: TIM4^-
• Gene: Timd4 Location: Chr11:46701627-46735159 bp, + strand Genetic Position: Chr11, 28.09 cM
• Alliance: Timd4^tm1Kuch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160747
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 2-4 were replaced with a neo cassette by homologous recombination. (J:160747)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Timd4 Mutation: 29 strains or lines available

References

• Original: J:160747 Rodriguez-Manzanet R, et al., T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice. Proc Natl Acad Sci U S A. 2010 May 11;107(19):8706-11
• All: 12 reference(s)