Pcsk1n^tm1Jep
Targeted Allele Detail

Summary

• Symbol: Pcsk1n^tm1Jep
• Name: proprotein convertase subtilisin/kexin type 1 inhibitor; targeted mutation 1, John E Pintar
• MGI ID: MGI:4459814
• Gene: Pcsk1n Location: ChrX:7786061-7790649 bp, + strand Genetic Position: ChrX, 3.57 cM, cytoband A1.1
• Alliance: Pcsk1n^tm1Jep page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161415
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted within intron 1 by homologous recombination. The absence of transcript was confirmed by Northern blot of whole brains from homozygous mutants. (J:161415)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pcsk1n Mutation: 13 strains or lines available

References

• Original: J:161415 Morgan DJ, et al., The propeptide precursor proSAAS is involved in fetal neuropeptide processing and body weight regulation. J Neurochem. 2010 Jun 1;113(5):1275-84
• All: 4 reference(s)