B3gnt5^tm1Nari
Targeted Allele Detail

Summary

• Symbol: B3gnt5^tm1Nari
• Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5; targeted mutation 1, Hisashi Narimatsu
• MGI ID: MGI:4459891
• Gene: B3gnt5 Location: Chr16:19578958-19591503 bp, + strand Genetic Position: Chr16, 12.23 cM, cytoband B1
• Alliance: B3gnt5^tm1Nari page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161366
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: The open reading frame containing exon 1 was replaced with a neomycin resistance gene by homologous recombination. RT-PCR confirmed the absence of the transcript in murine tissues. (J:161366)

Generation of the B3gnt5^tm1Nari allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any B3gnt5 Mutation: 24 strains or lines available

References

• Original: J:161366 Togayachi A, et al., Lack of lacto/neolacto-glycolipids enhances the formation of glycolipid-enriched microdomains, facilitating B cell activation. Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11900-5
• All: 1 reference(s)