Hif1an^tm1.2Rsjo
Targeted Allele Detail

Summary

• Symbol: Hif1an^tm1.2Rsjo
• Name: hypoxia-inducible factor 1, alpha subunit inhibitor; targeted mutation 1.2, Randall S Johnson
• MGI ID: MGI:4459899
• Synonyms: FIH^delta2
• Gene: Hif1an Location: Chr19:44551293-44564713 bp, + strand Genetic Position: Chr19, 37.98 cM, cytoband D1
• Alliance: Hif1an^tm1.2Rsjo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160941
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette was inserted within intron 1, with an additional loxP site with intron 2. The selection cassette and exon 2 were removed by cre mediated recombination. Western blot confirmed absence of protein in whole embryo lysates. (J:160941)

Expression

In Mice Carrying this Mutation:	71 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hif1an Mutation: 17 strains or lines available

References

• Original: J:160941 Zhang N, et al., The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism. Cell Metab. 2010 May 5;11(5):364-78
• All: 4 reference(s)