Chrm3tm1Abt
Targeted Allele Detail
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Symbol: |
Chrm3tm1Abt |
Name: |
cholinergic receptor, muscarinic 3, cardiac; targeted mutation 1, Andrew B Tobin |
MGI ID: |
MGI:4459925 |
Gene: |
Chrm3 Location: Chr13:9925522-10410883 bp, - strand Genetic Position: Chr13, 3.72 cM
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Alliance: |
Chrm3tm1Abt page
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Germline Transmission: |
Earliest citation of germline transmission:
J:160283
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129X1/SvJ
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Allele Type: |
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Targeted |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: The coding region was replaced with one containing 15 point mutations that altered serine to alanine at phospho-acceptor sites within the third intracellular loop (positions 285, 286, 288, 290, 291, 302, 303, 331, 332, 333, 335, 374, 379, 384, and 385). A neo cassette was inserted downstream of the modified coding region.
(J:160283)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Chrm3 Mutation: |
51 strains or lines available
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Original: |
J:160283 Poulin B, et al., The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9440-5 |
All: |
4 reference(s) |
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