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Chrm3tm1Abt
Targeted Allele Detail
Summary
Symbol: Chrm3tm1Abt
Name: cholinergic receptor, muscarinic 3, cardiac; targeted mutation 1, Andrew B Tobin
MGI ID: MGI:4459925
Gene: Chrm3  Location: Chr13:9925522-10410883 bp, - strand  Genetic Position: Chr13, 3.72 cM
Alliance: Chrm3tm1Abt page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:160283
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsThe coding region was replaced with one containing 15 point mutations that altered serine to alanine at phospho-acceptor sites within the third intracellular loop (positions 285, 286, 288, 290, 291, 302, 303, 331, 332, 333, 335, 374, 379, 384, and 385). A neo cassette was inserted downstream of the modified coding region. (J:160283)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chrm3 Mutation:  51 strains or lines available
References
Original:  J:160283 Poulin B, et al., The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9440-5
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory