Avil^tm2(cre)Fawa
Targeted Allele Detail

Summary

• Symbol: Avil^tm2(cre)Fawa
• Name: advillin; targeted mutation 2, Fan Wang
• MGI ID: MGI:4459942
• Synonyms: Advillin^Cre
• Gene: Avil Location: Chr10:126836578-126856863 bp, + strand Genetic Position: Chr10, 74.48 cM, cytoband D3
• Alliance: Avil^tm2(cre)Fawa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160568
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Avil^tm2(cre)Fawa expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Avil (MGI:1333798)

• Mutation details: A cre-IRES-EGFP was knocked into exon 2 of the Avil locus to achieve cre expression specifically within sensory neurons. Authors state that only male, not female, knockin animals are useful for sensory neuron-specific cre expression. The EGFP is nonfunctional. (J:160568, J:169302)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Avil (mouse) Summary of all recombinase alleles driven by Avil. Comparative matrix view of recombinase activities Alliance mouse Avil gene page

Expression

In Mice Carrying this Mutation:	4 assay results 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Avil Mutation: 47 strains or lines available

References

• Original: J:160568 Zhou X, et al., Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9424-9
• All: 111 reference(s)