Msh2^tm2.1Rak
Targeted Allele Detail

Summary

• Symbol: Msh2^tm2.1Rak
• Name: mutS homolog 2; targeted mutation 2.1, Raju Kucherlapati
• MGI ID: MGI:4460262
• Synonyms: M2CKO, MSH2CKO, MSH2CKO pGKneo flipped ou, Msh2^LoxP
• Gene: Msh2 Location: Chr17:87979960-88031141 bp, + strand Genetic Position: Chr17, 57.87 cM
• Alliance: Msh2^tm2.1Rak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161577
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt flanked neo cassette with a 5' loxP site was inserted upstream of exon 12, and an additional loxP site was inserted downstream of exon 12. Flp mediated recombination removed the neo cassette leaving exon 12 floxed. (J:161577)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Msh2^tm2.1Rak

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Msh2 Mutation: 95 strains or lines available

References

• Original: J:161577 Kucherlapati MH, et al., An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents. Gastroenterology. 2010 Mar;138(3):993-1002.e1
• All: 21 reference(s)