Msh2^tm2.2Rak
Targeted Allele Detail

Summary

• Symbol: Msh2^tm2.2Rak
• Name: mutS homolog 2; targeted mutation 2.2, Raju Kucherlapati
• MGI ID: MGI:4460263
• Synonyms: ECMsh2^LoxP, Msh2^delta12
• Gene: Msh2 Location: Chr17:87979960-88031141 bp, + strand Genetic Position: Chr17, 57.87 cM
• Alliance: Msh2^tm2.2Rak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161577
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre mediated recombination removed exon 12 from Msh2^tm2.1. The absence of protein expression was confirmed by western blot analysis on mouse embryonic fibroblast extracts. (J:161577)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Msh2 Mutation: 95 strains or lines available

References

• Original: J:161577 Kucherlapati MH, et al., An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents. Gastroenterology. 2010 Mar;138(3):993-1002.e1
• All: 3 reference(s)