Msh2^tm3.1Rak
Targeted Allele Detail

Summary

• Symbol: Msh2^tm3.1Rak
• Name: mutS homolog 2; targeted mutation 3.1, Raju Kucherlapati
• MGI ID: MGI:4460264
• Synonyms: Msh2^G674D
• Gene: Msh2 Location: Chr17:87979960-88031141 bp, + strand Genetic Position: Chr17, 57.87 cM
• Alliance: Msh2^tm3.1Rak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161577
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence, Hypomorph)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A floxed neo cassette was inserted upstream of modified exon 13 in which nucleotide substitutions (GGT to GAC) results in the amino acid substitution of aspartic acid for glycine at position 674 (G674D). Cre mediated recombination removed the neo cassette. (J:161577)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Msh2^tm3.1Rak

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Msh2 Mutation: 95 strains or lines available

References

• Original: J:161577 Kucherlapati MH, et al., An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents. Gastroenterology. 2010 Mar;138(3):993-1002.e1
• All: 1 reference(s)