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Krt9tm1(KOMP)Vlcg
Targeted Allele Detail
Summary
Symbol: Krt9tm1(KOMP)Vlcg
Name: keratin 9; targeted mutation 1, Velocigene
MGI ID: MGI:4460538
Gene: Krt9  Location: Chr11:100077607-100084072 bp, - strand  Genetic Position: Chr11, 63.43 cM
Alliance: Krt9tm1(KOMP)Vlcg page
IMPC: Krt9 gene page
Mutation
origin
Mutant Cell Lines:  10313A-A9, 10313A-A11, 10313A-B1, 10313A-C1, 10313A-C10, 10313A-E7
Germline Transmission:  Earliest citation of germline transmission: J:206051
Parent Cell Line:  VGB6 (ES Cell)
Strain of Origin:  C57BL/6NTac
Project Collection: KOMP-Regeneron
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: ZEN-Ub1
 
Mutation detailsThe insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 6142bp between positions 100077885-100084026 of Chromosome 11 (Build GRCm39). The cassette replaced the coding sequence. Immunoblotting confirmed the absence of protein expression in the plantar epidermis. (J:136110, J:206051)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Krt9 Mutation:  50 strains or lines available
Notes
Cell line 10313A-C10 was successfully used to make chimeric mice. Germline transmission was accomplished. J:206051
References
Original:  J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory