Bmp2^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Bmp2^{tm1(KOMP)Vlcg}
• Name: bone morphogenetic protein 2; targeted mutation 1, Velocigene
• MGI ID: MGI:4460567
• Gene: Bmp2 Location: Chr2:133394079-133404805 bp, + strand Genetic Position: Chr2, 65.21 cM
• Alliance: Bmp2^{tm1(KOMP)Vlcg} page
• IMPC: Bmp2 gene page

Mutation origin

• Mutant Cell Lines: 12406A-C11, 12406A-F11, 12406A-H3
• Germline Transmission: Earliest citation of germline transmission: J:258535
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 336bp between positions 133396349-133396684 of Chromosome 2 (Build GRCm39). Coding exon 1 is deleted beginning just after the start ATG to the end of coding exon 1, leaving the last 4 bp, and was replaced with a lacZ reporter cassette containing a floxed neomycin resistance gene under the control of the human ubiquitin promoter. (J:136110, J:258535)

Expression

In Mice Carrying this Mutation:	14 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 1 line available
• Carrying any Bmp2 Mutation: 27 strains or lines available

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 6 reference(s)