Slc4a8^tm1.1Doel
Targeted Allele Detail

Summary

• Symbol: Slc4a8^tm1.1Doel
• Name: solute carrier family 4 (anion exchanger), member 8; targeted mutation 1.1, Dominique Eladari
• MGI ID: MGI:4460780
• Synonyms: Ndcbe^-
• Gene: Slc4a8 Location: Chr15:100659628-100721849 bp, + strand Genetic Position: Chr15, 56.39 cM, cytoband F3
• Alliance: Slc4a8^tm1.1Doel page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161474
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Cre mediated recombination removed exon 12 and the neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:161474)

Generation of the Slc4a8^tm1.1Doel allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc4a8 Mutation: 55 strains or lines available

References

• Original: J:161474 Leviel F, et al., The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice. J Clin Invest. 2010 May 3;120(5):1627-35
• All: 4 reference(s)