Bmp4tm5.1Bhr
Targeted Allele Detail
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Symbol: |
Bmp4tm5.1Bhr |
Name: |
bone morphogenetic protein 4; targeted mutation 5.1, Richard R Behringer |
MGI ID: |
MGI:4460795 |
Synonyms: |
Bmp4CFP |
Gene: |
Bmp4 Location: Chr14:46620982-46628126 bp, - strand Genetic Position: Chr14, 23.95 cM
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Alliance: |
Bmp4tm5.1Bhr page
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutation: |
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Insertion
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Mutation details: A floxed Pgk-neo-bpA cassette was inserted into the Eco RI site into the preserved third intron in reverse orientation. An improved YFP, Citrine, coding sequence was inserted into the fourth exon as an in-frame fusion after the furin cleavage site that generates the mature peptide. The floxed Neo cassette was removed through crossing with Sox2-Cre transgenic animals. Although no endogenous sequence was deleted, this allele was determined to be functionally null allele.
(J:159629)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Bmp4 Mutation: |
23 strains or lines available
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Original: |
J:159629 Jang CW, et al., Bmp4-directed nuclear cyan fluorescent protein provides a tool for live imaging and reveals cellular resolution of Bmp4 expression patterns during embryogenesis. Int J Dev Biol. 2010;54(5):931-8 |
All: |
3 reference(s) |
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