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Bmp4tm5.1Bhr
Targeted Allele Detail
Summary
Symbol: Bmp4tm5.1Bhr
Name: bone morphogenetic protein 4; targeted mutation 5.1, Richard R Behringer
MGI ID: MGI:4460795
Synonyms: Bmp4CFP
Gene: Bmp4  Location: Chr14:46620982-46628126 bp, - strand  Genetic Position: Chr14, 23.95 cM
Alliance: Bmp4tm5.1Bhr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:159629
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA floxed Pgk-neo-bpA cassette was inserted into the Eco RI site into the preserved third intron in reverse orientation. An improved YFP, Citrine, coding sequence was inserted into the fourth exon as an in-frame fusion after the furin cleavage site that generates the mature peptide. The floxed Neo cassette was removed through crossing with Sox2-Cre transgenic animals. Although no endogenous sequence was deleted, this allele was determined to be functionally null allele. (J:159629)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 27 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bmp4 Mutation:  23 strains or lines available
References
Original:  J:159629 Jang CW, et al., Bmp4-directed nuclear cyan fluorescent protein provides a tool for live imaging and reveals cellular resolution of Bmp4 expression patterns during embryogenesis. Int J Dev Biol. 2010;54(5):931-8
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory